Commercial Scalable Process for the Preparation of Irbesartan Intermediate
نویسندگان
چکیده
Development of efficient commercial process for the preparation of highly pure 4'-(2-Butyl-4-oxo-1,3-diazaspiro[4,4]non-1-en-3-ylmethyl)-biphenyl-2-carbonitrile (1), an advanced intermediate of Irbesartan is described. The developed process minimizes the impurity formation and utilizes the simplified process to improve yield, throughput and is suitable for production on commercial scale.
منابع مشابه
An improved and efficient synthesis of Irbesartan, an antihypertensive drug
Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation.
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